Manchester United striker Rasmus Hojlund and £52m new signing Leny Yoro both suffered first-half injuries as the Red Devils lost their opening US tour game against Premier League rivals Arsenal 2-1 in Los Angeles.
Hojlund had given his side a 10th-minute lead before seeming to experience a muscle injury after 15 minutes.
Gunners forward Gabriel Jesus levelled with a close range finish after 25 minutes, before substitute Gabriel Martinelli cut inside 17-year-old rookie full-back James Scanlon to score the winner.
United did triumph in a pre-arranged penalty shoot-out that followed, with Jadon Sancho scoring the decisive spot-kick to seal a 4-3 win.
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