Kane then rounded off the win with a closerange strike after a goalmouth scramble. The goal was his 63rd in international football, taking him one ahead of Ronaldo.
Juve's 42-year-old goalkeeper Gianluigi Buffon prevented Parma from taking an early lead when he saved with his legs from Juraj Kucka's close-range effort before the Turin side took complete control.
Barca went ahead when Neymar finished off a fine team move by scoring from closerange after Messi's pass. But Villarreal levelled when Cedric Bakambu sprinted clear of Gerard Pique.
But it was the Catalan side who struck first when Lamine Yamal drove down the right-hand side, beating Nuno Mendes and clipping over for Raphinha to score from closerange.
Messi's sublime 20-yard free-kick levelled before he teed up Gerard Pique to sidefoot in the close-range winner. Barca, who have not lost in 34 games, are now eight points clear in La Liga.
Chelsea, who won the first leg 1-0, doubled their aggregate lead through Pedro after only five minutes Shortly after, Pedro somehow hit the post from closerange but the ball went it on off Simon Deli to make it 2-0.
Memphis Depay's close-range finish put United in front in the 37th minute, but Pione Sisto -- capitalising on a Michael Carrick error -- equalised seven minutes later, and a fine strike from Midtjylland substitute Paul Onuachu with 13 minutes
In the 24th minute the Eagles went close again but Akwa United star Alhassan headed over the bar from closerange after a brilliant cross from Echiejile.
The 28-year-old had been superb in Tuesday's match, until Marcus Berg nodded home the opener from closerange in the 51st minute. Shortly afterwards, De Gea sat down on the pitch, before being replaced by Kepa Arrizabalaga.
City, needing three points to become champions of England for the seventh time, took the lead just before half-time through Raheem Sterling's close-range strike.
Slick passing opened the Ahly defence and the midfielder struck the ball wide of goalkeeper Mohamed el Shenawy from closerange and into the far corner of the net.
The five-time Ballon d'Or winner converted a penalty in the 72nd minute, after a Ukraine player was judged to have handled a long-range shot in the box.